Camsap3 Gene Summary [Rat]
Predicted to enable actin filament binding activity and microtubule minus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; regulation of microtubule polymerization or depolymerization; and zonula adherens maintenance. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytoskeleton; motile cilium; and zonula adherens. Predicted to colocalize with microtubule minus-end. Orthologous to human CAMSAP3 (calmodulin regulated spectrin associated protein family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camsap3 |
| Official Name | calmodulin regulated spectrin-associated protein family, member 3 [Source:RGD Symbol;Acc:1597412] |
| Ensembl ID | ENSRNOG00000000986 |
| Bio databases IDs | |
| Aliases | calmodulin regulated spectrin-associated protein family, member 3 |
| Synonyms | 2310057J16Rik, calmodulin regulated spectrin associated protein family member 3, calmodulin regulated spectrin-associated protein family, member 3, KIAA1543, LOC682941, NEZHA, PPP1R80, RGD1307246 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camsap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- microtubule binding
- Spectrin-binding region of Ca2+-Calmodulin
- calponin homology (CH) domain superfamily
- Microtubule-binding calmodulin-regulated spectrin-associated
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- olfaction disorder
regulates
- tubulin (family)
- mucin
role in cell
- beat
- migration
- morphology
- number
- assembly
- organization
- loss
- positioning
- polymerization
- orientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- microtubule cytoskeleton
- cell cortex
- basal bodies
- centrosome
- axonemes
- apical cortex
- zonula adherens
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camsap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- microtubule anchoring
- neuron projection development
- epithelial cell-cell adhesion
- regulation of organelle organization
- embryo development ending in birth or egg hatching
- replication fork arrest
- microtubule cytoskeleton organization
- cilium movement
- zonula adherens maintenance
- regulation of focal adhesion assembly
- DNA replication checkpoint
- in utero embryonic development
- establishment of epithelial cell apical/basal polarity
- regulation of microtubule polymerization
- regulation of cell migration
- establishment or maintenance of microtubule cytoskeleton polarity
Cellular Component
Where in the cell the gene product is active
- centrosome
- motile cilium
- cilium basal body
- cytoplasm
- zonula adherens
- replication fork protection complex
- axoneme
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- DNA binding
- calmodulin binding
- protein binding
- spectrin binding
- microtubule minus-end binding