Spag16 Gene Summary [Rat]
Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Spag16 |
| Official Name | sperm associated antigen 16 [Source:RGD Symbol;Acc:1565062] |
| Ensembl ID | ENSRNOG00000042609 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 16 |
| Synonyms | 4921511D23RIK, 4930524F24Rik, 4930585K05Rik, AV261009, PF20, RGD1565062, Riken cDNA 4921511d23, sperm associated antigen 16, WDR29 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spag16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- asthenozoospermia
- osteoarthritis
- metabolic syndrome X
- multiple sclerosis
- teratozoospermia
- colorectal cancer
- attention deficit hyperactivity disorder
- pervasive developmental disorder
- major depression
role in cell
- apoptosis
- quantity
- morphology
- abnormal morphology
- motility
- spermatogenesis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- flagella
- microtubules
- axonemes
- central apparatus
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spag16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- axoneme assembly
- sperm axoneme assembly
Cellular Component
Where in the cell the gene product is active
- sperm flagellum
- extracellular region
- axoneme