Adcy6 Gene Summary [Rat]
Enables several functions, including SNARE binding activity; calcium- and calmodulin-responsive adenylate cyclase activity; and protein kinase binding activity. Involved in several processes, including cAMP biosynthetic process; maintenance of protein location in plasma membrane; and negative regulation of neuron projection development. Located in endosome; microvillus membrane; and sarcolemma. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (adenylate cyclase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy6 |
| Official Name | adenylate cyclase 6 [Source:RGD Symbol;Acc:2035] |
| Ensembl ID | ENSRNOG00000054757 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 6 |
| Synonyms | AC6, ACVI, ADCYB, adenylate cyclase 6, Adenylyl cyclase VI, LCCS8, mKIAA0422 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcy6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- RXXs motif
- protein kinase binding
- protein kinase C binding
- C1A domain
- Adenylyl cyclase N-terminal extracellular and transmembrane region
- enzyme
- protein binding
- receptor binding
- Adenylate cyclase, conserved domain
- PXsP motif
- adenylate cyclase
- transmembrane domain
- calcium/calmodulin-responsive adenylate cyclase
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- Serine Proline motif
Pathways
Biological processes and signaling networks where the Adcy6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- diverticulitis
- lethal congenital contracture syndrome type 8
- polyuria
role in cell
- apoptosis
- activation in
- phosphorylation in
- production in
- accumulation in
- development
- outgrowth
- permeabilization
- arborization
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- endosomes
- primary cilia
- growth cone
- sarcolemma
- membrane rafts
- microvilli
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcy6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cAMP biosynthetic process
- renal water homeostasis
- negative regulation of neuron projection development
- cellular response to catecholamine stimulus
- negative regulation of urine volume
- dopamine receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane
- cilium
- stereocilium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein kinase binding
- ATP binding
- protein binding
- metal ion binding
- adenylate cyclase activity