Spag16 Gene Summary [Mouse]
Enables protein kinase binding activity. Involved in cilium assembly. Acts upstream of or within cerebrospinal fluid circulation; mucociliary clearance; and sperm axoneme assembly. Located in axonemal central apparatus and sperm flagellum. Orthologous to human SPAG16 (sperm associated antigen 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Spag16 |
| Official Name | sperm associated antigen 16 [Source:MGI Symbol;Acc:MGI:1913972] |
| Ensembl ID | ENSMUSG00000053153 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 16 |
| Synonyms | 4921511D23RIK, 4930524F24Rik, 4930585K05Rik, AV261009, PF20, RGD1565062, Riken cDNA 4921511d23, sperm associated antigen 16, WDR29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- asthenozoospermia
- osteoarthritis
- metabolic syndrome X
- multiple sclerosis
- teratozoospermia
- colorectal cancer
- attention deficit hyperactivity disorder
- pervasive developmental disorder
- major depression
role in cell
- apoptosis
- quantity
- morphology
- abnormal morphology
- motility
- spermatogenesis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- flagella
- microtubules
- axonemes
- central apparatus
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spag16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- axoneme assembly
- sperm axoneme assembly
Cellular Component
Where in the cell the gene product is active
- sperm flagellum
- extracellular region
- axoneme