Tipin Gene Summary [Rat]
The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | Tipin |
| Official Name | timeless interacting protein [Source:RGD Symbol;Acc:1564084] |
| Ensembl ID | ENSRNOG00000043068 |
| Bio databases IDs | |
| Aliases | timeless interacting protein |
| Synonyms | 1110005A05Rik, 1110018P21Rik, FLJ20516, RGD1564084, TIMELESS interacting protein, UV98 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tipin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Replication Fork Protection Component Swi3
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- nonsyndromic cleft lip and palate
- organismal death
- renal cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- proliferation
- telomeric mitotic DNA synthesis in
- clustering in
- S phase checkpoint control
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tipin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA replication checkpoint
- positive regulation of cell proliferation
- regulation of DNA replication involved in S phase
- replication fork arrest
- response to UV
- replication fork processing
- intra-S DNA damage checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- replication fork protection complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding