Micu1 Gene Summary [Rat]
Predicted to enable several functions, including calcium channel inhibitor activity; calcium ion sensor activity; and protein heterodimerization activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to calcium ion starvation; and positive regulation of cristae formation. Predicted to be located in mitochondrial crista junction and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Micu1 |
| Official Name | mitochondrial calcium uptake 1 [Source:RGD Symbol;Acc:735033] |
| Ensembl ID | ENSRNOG00000043436 |
| Bio databases IDs | |
| Aliases | mitochondrial calcium uptake 1 |
| Synonyms | ara CALC, C730016L05Rik, CALC, CBARA1, EFHA3, LOC100360636, LOC100360686, LOC100362065, mitochondrial calcium uptake 1, MPXPS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Micu1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- calcium channel inhibitor
- EF hand
- calcium ion binding
- protein binding
- EFh_MICU
- identical protein binding
- calcium channel regulator
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Micu1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sarcoidosis
- myopathy with extrapyramidal signs
- Parkinson disease with dementia
- hereditary disorder
- neurodevelopmental disorder
- mitochondrial disorder
- refractive error
role in cell
- expression in
- activation in
- proliferation
- ferroptosis
- response by
- transport in
- stabilization in
- peroxidation in
- handling in
- Gap 0-Gap 1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Micu1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- elevation of mitochondrial calcium ion concentration
- mitochondrial calcium ion homeostasis
- protein homooligomerization
- regulation of cellular hyperosmotic salinity response
- defense response
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- calcium channel complex
- mitochondrial membrane
- mitochondrial crista junction
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein heterodimerization activity
- calcium ion binding
- calcium channel inhibitor activity