Capn10 Gene Summary [Rat]
Enables SNARE binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including autophagy of mitochondrion; positive regulation of apoptotic process; and response to glucose. Located in several cellular components, including cytoskeleton; cytosol; and mitochondrion. Used to study type 2 diabetes mellitus. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human CAPN10 (calpain 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn10 |
| Official Name | calpain 10 [Source:RGD Symbol;Acc:69354] |
| Ensembl ID | ENSRNOG00000045623 |
| Bio databases IDs | |
| Aliases | calpain 10 |
| Synonyms | AI430010, calpain 10, CANP10, Capn8, mKIAA1845, NIDDM1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Calpain family cysteine protease
- cytoskeletal protein binding
- calpain
- peptidase
- protein binding
- Calpain_III
- CysPc
Pathways
Biological processes and signaling networks where the Capn10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- noninsulin-dependent diabetes mellitus 1
- autosomal recessive nonsyndromic mental retardation
- hereditary disorder
- susceptibility to polycystic ovary syndrome
regulates
- D-glucose
- insulin
- ADRB3
role in cell
- apoptosis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial outer membrane
- mitochondrial inner membrane
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Capn10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- cellular component disassembly involved in apoptotic process
- regulation of actin cytoskeleton organization
- proteolysis
- positive regulation of intracellular transport
- positive regulation of glucose import
- positive regulation of type B pancreatic cell apoptotic process
- type B pancreatic cell apoptotic process
- positive regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium-dependent cysteine-type endopeptidase activity
- SNARE binding
- cytoskeletal protein binding