LOC108348108 Gene Summary [Rat]
Enables NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of release of cytochrome c from mitochondria; negative regulation of vasoconstriction; and positive regulation of T cell mediated cytotoxicity. Located in apical plasma membrane; basolateral plasma membrane; and membrane raft. Part of protein-containing complex. Biomarker of graft-versus-host disease. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348108 |
| Official Name | heat shock 70 kDa protein 1A [Source:RGD Symbol;Acc:11425585] |
| Ensembl ID | ENSRNOG00000045654 |
| Bio databases IDs | |
| Aliases | heat shock 70 kDa protein 1A |
| Synonyms | heat shock protein family A (Hsp70) member 1A, heat shock protein family A (Hsp70) member 1B, HSP70, HSP70-1, HSP70.1, HSP70-2, HSP70.2, HSP72, Hspa1, Hspa1a, Hspa1b |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348108 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protease binding
- NF-kappaB binding
- transcription co-repressor
- heat shock protein binding
- G-protein-coupled receptor binding
- ATP binding
- enzyme binding
- histone deacetylase binding
- protein domain specific binding
- enzyme
- protein binding
- receptor binding
- ATPase
- Fe-S protein assembly chaperone HscA
- chaperone protein DnaK
- receptor agonist activity
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Loc108348108 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- 3,4,5,3',4'-pentachlorobiphenyl
- testosterone
- mercuric chloride
- desmopressin
- fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether
- quinolinic acid
- methylprednisolone
- tetrachlorodibenzodioxin
- 2,3,4,7,8-pentachlorodibenzofuran
- cadmium chloride
regulates
- cytochrome C
- NFkB (complex)
- JINK1/2
- SOD
- malondialdehyde
- CAT
- glutathione
role in cell
- apoptosis
- differentiation
- cytotoxicity
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- Extracellular Space
- intracellular space
- perinuclear region
- Nucleus
- centrosome
- centriole
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane
- nuclear speckles
- membrane rafts
- perikaryon