Nox4 Gene Summary [Rat]
Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to mercury ion. Located in several cellular components, including endoplasmic reticulum; focal adhesion; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction-associated steatohepatitis; obesity; and steatotic liver disease. Orthologous to human NOX4 (NADPH oxidase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nox4 |
| Official Name | NADPH oxidase 4 [Source:RGD Symbol;Acc:620600] |
| Ensembl ID | ENSRNOG00000013925 |
| Bio databases IDs | |
| Aliases | NADPH oxidase 4 |
| Synonyms | KOX, KOX-1, NADPH oxidase 4, RENOX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nox4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- electron carrier
- flavin adenine dinucleotide binding
- FAD binding domain
- nucleotide binding
- protein kinase binding
- Cytochrome_b_N
- heme binding domain
- enzyme
- protein binding
- heme binding
- superoxide-generating NADPH oxidase
- oxygen sensor
- binding protein
- transmembrane domain
- NADPH oxidase
- loop domain
- oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
- Oxidoreductase NAD-binding domain
- NADPH binding domain
Pathways
Biological processes and signaling networks where the Nox4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- cancer
- epithelial cancer
- melanoma
- melanoma cancer
- liver cancer
- bradycardia
- survival
- diabetic nephropathy
role in cell
- expression in
- activation
- binding in
- cell death
- survival
- activation in
- growth
- apoptosis
- proliferation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- apical membrane
- inner nuclear membrane
- perinuclear space
- nucleoli
- outer nuclear membrane
- nuclear envelope
- actin stress fibers
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nox4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell morphogenesis
- positive regulation of protein tyrosine kinase activity
- negative regulation of cell proliferation
- superoxide anion generation
- defense response
- heart process
- inflammatory response
- superoxide metabolic process
- cellular response to glucose stimulus
- bone resorption
- positive regulation of ERK1 and ERK2 cascade
- gene expression
- homocysteine metabolic process
- cardiac muscle cell differentiation
- positive regulation of DNA biosynthetic process
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- perinuclear region of cytoplasm
- perinuclear endoplasmic reticulum
- focal adhesion
- NADPH oxidase complex
- membrane
- mitochondrion
- endoplasmic reticulum
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- modified amino acid binding
- nucleotide binding
- protein binding
- oxygen sensor activity
- flavin adenine dinucleotide binding
- electron carrier activity
- NAD(P)H oxidase activity
- superoxide-generating NADPH oxidase activity
- heme binding