Tmx3 Gene Summary [Rat]
Predicted to enable protein-disulfide reductase activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cell surface and endoplasmic reticulum. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmx3 |
| Official Name | thioredoxin-related transmembrane protein 3 [Source:RGD Symbol;Acc:1592777] |
| Ensembl ID | ENSRNOG00000045740 |
| Bio databases IDs | |
| Aliases | thioredoxin-related transmembrane protein 3 |
| Synonyms | 6430411B10Rik, A730024F05Rik, FLJ20793, mKIAA1830, PDIA13, thioredoxin-related transmembrane protein 3, TXNDC10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calsequestrin
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein disulfide-isomerase domain
- enzyme
- protein binding
- thioredoxin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmx3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- platelet alpha granule membrane
- endoplasmic reticulum
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide oxidoreductase activity
- protein disulfide isomerase activity