Cldn3 Gene Summary [Rat]
Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and structural molecule activity. Involved in response to Gram-positive bacterium and response to ethanol. Located in bicellular tight junction and lateral plasma membrane. Biomarker of peptic esophagitis. Orthologous to human CLDN3 (claudin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn3 |
| Official Name | claudin 3 [Source:RGD Symbol;Acc:68425] |
| Ensembl ID | ENSRNOG00000046007 |
| Bio databases IDs | |
| Aliases | claudin 3 |
| Synonyms | C7orf1, claudin 3, CPE-R2, CPETR2, HRVP1, mRVP1, RVP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell adhesion molecule binding
- PMP-22/EMP/MP20/Claudin family
- NPLVP motif
- extracellular loop
- protein binding
- structural molecule
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cldn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- ovarian carcinoma
- epithelial ovarian cancer
- endometriosis
- uterine carcinosarcoma
- Müllerian cancer
- uterine cancer
- metastatic colon cancer
role in cell
- proliferation
- invasion
- survival
- migration
- morphogenesis
- organization
- formation
- motility
- assembly
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apicolateral membrane
- Cytoplasm
- cell surface
- cellular membrane
- intercellular junctions
- cell-cell contacts
- tight junctional strands
- lateral plasma membrane
- tight junctions
- junctional complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- calcium-independent cell-cell adhesion
- establishment of endothelial blood-brain barrier
- positive regulation of wound healing
- regulation of cell morphogenesis
- cell junction maintenance
- negative regulation of cell proliferation
- epithelial cell morphogenesis
- cell adhesion
- response to ethanol
- negative regulation of gene expression
- response to hypoxia
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- tight junction assembly
- actin cytoskeleton organization
- maintenance of blood-brain barrier
- negative regulation of cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- apicolateral plasma membrane
- lateral plasma membrane
- occluding junction
- tight junction
- cell-cell junction
- membrane
- apical junction complex
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane signaling receptor activity
- structural molecule activity