Bptf Gene Summary [Rat]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Involved in cellular response to nerve growth factor stimulus. Located in cell body; dendrite; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Kaposi's sarcoma; alcohol dependence; and neurodevelopmental disorder with dysmorphic facies and distal limb anomalies. Orthologous to human BPTF (bromodomain PHD finger transcription factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bptf |
| Official Name | bromodomain PHD finger transcription factor [Source:RGD Symbol;Acc:1307039] |
| Ensembl ID | ENSRNOG00000047296 |
| Bio databases IDs | |
| Aliases | bromodomain PHD finger transcription factor |
| Synonyms | 9430093H17Rik, bromodomain PHD finger transcription factor, circBPTF, circRNA-BPTF, FAC1, FALZ, NEDDFL, NURF301 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bptf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- nuclear export signal
- nuclear localization sequence
- DDT domain
- transcription factor binding
- protein binding
- DNA dependent ATPase
- Bromodomain
- sequence-specific DNA binding
- acidic domain
- PEST domain
- Williams-Beuren syndrome DDT (WSD), D-TOX E motif
- PHD finger superfamily
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- major depression
- endometrial carcinoma
- insomnia
- anxiety disorder
- neurodevelopmental disorder
- COVID-19
- hereditary disorder
- rheumatoid arthritis
- post-traumatic stress disorder
role in cell
- proliferation
- migration
- outgrowth
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- nucleoplasm
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bptf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- endoderm development
- anterior/posterior pattern specification
- regulation of transcription, DNA-dependent
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- embryonic placenta development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- cell body
- chromatin
- NURF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-dependent ATPase activity
- protein binding
- metal ion binding
- methylated histone residue binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding