Tfap4 Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfap4 |
| Official Name | transcription factor AP-4 [Source:RGD Symbol;Acc:1308357] |
| Ensembl ID | ENSRNOG00000005227 |
| Bio databases IDs | |
| Aliases | transcription factor AP-4 |
| Synonyms | AP-4, bHLHc41, D930048N17Rik, TCFAP4, transcription factor AP-4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- degron
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- histone deacetylase binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- protein homodimerization
- helix-loop-helix domain
- paxillin LD motif
- Helix-loop-helix DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- organismal death
- chronic lymphocytic leukemia
- infection by HIV-1
role in cell
- expression in
- apoptosis
- formation
- formation in
- proliferation
- migration
- differentiation
- growth
- invasion
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tfap4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation by host of viral transcription
- negative regulation by host of viral transcription
- macromolecular complex assembly
- negative regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- negative regulation of gene expression
- negative regulation of DNA binding
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- cellular response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding