Ggt1 Gene Summary [Rat]
Enables aminoacyltransferase activity. Involved in several processes, including liver development; response to estradiol; and response to tumor necrosis factor. Located in extracellular space. Biomarker of aflatoxins-related hepatocellular carcinoma and alcohol dependence. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ggt1 |
| Official Name | gamma-glutamyltransferase 1 [Source:RGD Symbol;Acc:2683] |
| Ensembl ID | ENSRNOG00000047697 |
| Bio databases IDs | |
| Aliases | gamma-glutamyltransferase 1 |
| Synonyms | Alpha1-GGT, CD224, D22S672, D22S732, dwg, gamma-glutamyltransferase 1, Gamma-glutamyl transpeptidase, Gamma-Gt, GGLUT, GGT, GGTD, GGTP, GTG, γ-glutamyltransferase 1, γ-glutamyl transpeptidase, γ-Gt |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ggt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aminoacyltransferase
- peptidyltransferase
- Gamma-glutamyltranspeptidase
- omega peptidase
- peptidase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ggt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteopenia
- cataract disease
- hypoplasia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- disproportionate dwarfism
- non-small cell lung cancer
- peptic ulcer disease
- gastric ulcer
role in cell
- apoptosis
- proliferation
- ferroptosis
- growth
- activation in
- formation
- degeneration
- quantity
- activity
- oxidative stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ggt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene metabolic process
- spermatogenesis
- glutathione biosynthetic process
- glutathione catabolic process
- cellular amino acid metabolic process
- regulation of immune system process
- fatty acid metabolic process
- zymogen activation
- glutamate metabolic process
- proteolysis
- cysteine biosynthetic process
- regulation of inflammatory response
- peptide modification
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidyltransferase activity