GGT1 Gene Summary [Human]
The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | GGT1 |
| Official Name | gamma-glutamyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:4250] |
| Ensembl ID | ENSG00000100031 |
| Bio databases IDs | |
| Aliases | gamma-glutamyltransferase 1 |
| Synonyms | Alpha1-GGT, CD224, D22S672, D22S732, dwg, gamma-glutamyltransferase 1, Gamma-glutamyl transpeptidase, Gamma-Gt, GGLUT, GGT, GGTD, GGTP, GTG, γ-glutamyltransferase 1, γ-glutamyl transpeptidase, γ-Gt |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aminoacyltransferase
- peptidyltransferase
- Gamma-glutamyltranspeptidase
- omega peptidase
- peptidase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the GGT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteopenia
- cataract disease
- hypoplasia
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- disproportionate dwarfism
- non-small cell lung cancer
- peptic ulcer disease
- gastric ulcer
role in cell
- apoptosis
- proliferation
- ferroptosis
- growth
- activation in
- formation
- degeneration
- quantity
- activity
- oxidative stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene metabolic process
- spermatogenesis
- glutathione biosynthetic process
- glutathione catabolic process
- cellular amino acid metabolic process
- regulation of immune system process
- fatty acid metabolic process
- zymogen activation
- glutamate metabolic process
- proteolysis
- cysteine biosynthetic process
- regulation of inflammatory response
- peptide modification
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidyltransferase activity