Pip5kl1 Gene Summary [Rat]
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in cell projection and cytosol. Predicted to be active in plasma membrane. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pip5kl1 |
| Official Name | phosphatidylinositol-4-phosphate 5-kinase-like 1 [Source:RGD Symbol;Acc:1597527] |
| Ensembl ID | ENSRNOG00000048676 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 5-kinase-like 1 |
| Synonyms | phosphatidylinositol-4-phosphate 5-kinase-like 1, PIPKH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pip5kl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
- Phosphatidylinositol-4-phosphate 5-Kinase
- protein binding
- 1-phosphatidylinositol-4-phosphate 5-kinase
Pathways
Biological processes and signaling networks where the Pip5kl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pip5kl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitochondrial membrane potential
- negative regulation of protein phosphorylation
- positive regulation of apoptotic process
- phosphatidylinositol phosphorylation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytosol
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- 1-phosphatidylinositol-4-phosphate 5-kinase activity