LSM2 Gene Summary [Human]

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

Details

Type
Processed Transcript
Official Symbol
LSM2
Official Name
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:13940]
Ensembl ID
ENSG00000172850
Bio databases IDs NCBI: 57819 Ensembl: ENSG00000172850
Aliases LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms C6orf28, D17H6S56E-2, Dmapl, DMPKAP, G7B, LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated, Sm-X5, snRNP, YBL026W
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LSM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sm and related proteins
  • protein kinase binding
  • enzyme binding
  • protein binding

Pathways

Biological processes and signaling networks where the LSM2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cutaneous melanoma
  • cutaneous melanoma cancer
  • inguinal hernia
  • organismal death
  • lymphomagenesis
  • pneumonia
  • lymphoma
regulated by
regulates
  • snRNP
role in cell
  • proliferation
  • migration
  • invasion by
  • splicing by
  • homologous recombination in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • catalytic step 2 spliceosome
  • Cytoplasm
  • cytosol
  • spliceosomes
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human LSM2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • mRNA catabolic process
  • assembly of spliceosomal tri-snRNP
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • catalytic step 2 spliceosome
  • cytoplasm
  • precatalytic spliceosome
  • U4/U6 x U5 tri-snRNP complex
  • cytosol
  • cytoplasmic mRNA processing body
  • U2-type precatalytic spliceosome
  • U6 snRNP
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • U6 snRNA binding
  • protein binding
  • RNA binding
  • small GTPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.