Hadha Gene Summary [Rat]
Enables several functions, including 3-hydroxyacyl-CoA dehydratase activity; heterocyclic compound binding activity; and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in fatty acid beta-oxidation and response to xenobiotic stimulus. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in mitochondrial trifunctional protein deficiency 1 and steatotic liver disease. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hadha |
| Official Name | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [Source:RGD Symbol;Acc:620512] |
| Ensembl ID | ENSRNOG00000024629 |
| Bio databases IDs | |
| Aliases | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
| Synonyms | ECHA, Enoyl-CoA Hydratase, GBP, HADH, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit α, LCEH, LCHAD, Mitochondrial long chain enoyl CoA hydratase, Mitochondrial trifunctional protein alpha, Mitochondrial trifunctional protein α, MTPA, RGD1560655, TP-ALPHA, TP-α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hadha often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
- 3-hydroxyacyl-CoA dehydrogenase
- crotonase-like
- fatty oxidation complex, alpha subunit FadJ
- fatty acid oxidation complex, alpha subunit, mitochondrial
- acetyl-CoA C-acetyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- long-chain-3-hydroxyacyl-CoA dehydrogenase
- signal peptide peptidase SppA, 36K type
- enoyl-CoA hydratase
- acetyl-CoA C-acyltransferase
- NAD or NADH binding
- binding protein
- 3-hydroxyacyl-CoA dehydratase
- acyl-CoA binding
- 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA hydrolase
- Enoyl-CoA hydratase/isomerase
Pathways
Biological processes and signaling networks where the Hadha gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- hepatocellular carcinoma
- hypoglycemia
- neoplasia
- epithelial cancer
- Alzheimer disease
- liver cancer
- metastasis
- advanced cancer
- hepatic steatosis
role in cell
- formation
- proliferation
- formation in
- production in
- expression in
- growth
- phosphorylation in
- degeneration
- migration
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cellular membrane
- Mitochondria
- myofilaments
- lipid droplets
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial nucleoids
- mitochondrial inner membrane
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hadha gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- response to insulin stimulus
- cardiolipin acyl-chain remodeling
- response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- mitochondrial fatty acid beta-oxidation multienzyme complex
- mitochondrion
- mitochondrial inner membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- 3-hydroxyacyl-CoA dehydratase activity
- acetyl-CoA C-acetyltransferase activity
- protein binding
- 3-hydroxyacyl-CoA dehydrogenase activity
- fatty-acyl-CoA binding
- long-chain-3-hydroxyacyl-CoA dehydrogenase activity
- enoyl-CoA hydratase activity
- NAD+ binding