Cryba4 Gene Summary [Rat]
A structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Biomarker of cataract. Human ortholog(s) of this gene implicated in cataract 23. Orthologous to human CRYBA4 (crystallin beta A4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cryba4 |
| Official Name | crystallin, beta A4 [Source:RGD Symbol;Acc:61962] |
| Ensembl ID | ENSRNOG00000049770 |
| Bio databases IDs | |
| Aliases | crystallin, beta A4 |
| Synonyms | crystallin beta A4, crystallin, beta A4, crystallin β A4, crystallin, β A4, CTRCT23, CYRBA4, MCOPCT4, β a4 crystallin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cryba4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- protein binding
- identical protein binding
- Beta/Gamma crystallin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- lamellar cataract type 23
- high myopia
- nuclear cataract 23 with microcornea
- multiple types cataract 23
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cryba4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- camera-type eye development
- lens development in camera-type eye
- visual perception
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- structural constituent of eye lens