Celf1 Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity. Involved in cellular response to polyamine macromolecule; negative regulation of epithelial cell proliferation; and post-transcriptional regulation of gene expression. Acts upstream of or within positive regulation of gene expression. Predicted to be located in cytoplasmic stress granule and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Celf1 |
| Official Name | CUGBP, Elav-like family member 1 [Source:RGD Symbol;Acc:1307721] |
| Ensembl ID | ENSRNOG00000010379 |
| Bio databases IDs | |
| Aliases | CUGBP, Elav-like family member 1 |
| Synonyms | 1600010O03RIK, BRUNOL2, CUG-BP, CUG-BP1, CUGBP Elav-like family member 1, CUGBP, Elav-like family member 1, D2Wsu101e, EDEN-BP, HNAB50, NAB50, NAPOR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Celf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- mRNA binding
- BRE binding
- protein binding
- translation regulator
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- Alzheimer disease
- liver neoplasm
- liver neoplasia
- non-insulin-dependent diabetes mellitus
- nonlobar intracerebral hemorrhage
- overnutrition
role in cell
- expression in
- proliferation
- apoptosis
- binding in
- production in
- cell cycle progression
- degeneration
- development
- alternative splicing by
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- polysomes
- perinucleolar compartments
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Celf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- mRNA destabilization
- posttranscriptional gene silencing by RNA
- embryo development ending in birth or egg hatching
- negative regulation of cell proliferation
- mRNA splice site selection
- mRNA processing
- negative regulation of gene expression
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of RNA splicing
- positive regulation of gene expression
- regulation of inflammatory response
- posttranscriptional gene silencing
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- BRE binding
- protein binding
- RNA binding
- translation repressor activity, nucleic acid binding
- mRNA binding
- mRNA 3'-UTR binding