Maf Gene Summary [Rat]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maf |
| Official Name | MAF bZIP transcription factor [Source:RGD Symbol;Acc:3034] |
| Ensembl ID | ENSRNOG00000012428 |
| Bio databases IDs | |
| Aliases | MAF bZIP transcription factor |
| Synonyms | 2810401A20Rik, A230108G15RIK, AW047063, AYGRP, CCA4, c-MAF, CTRCT21, LOC105371352, LOC108348985, Maf2, MAF bZIP transcription factor, V-MAF MUSCULOAPONEUROTIC FIBROSARCOMA ONCOGENE HOMOLOG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Maf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Maf N-terminal region
- transcription regulator
- transcription activation domain
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- leucine-rich repeat
- binding protein
- double-stranded DNA binding
- basic domain
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Maf gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- early-onset preeclampsia
- diabetes mellitus
- Ayme-Gripp syndrome
- congenital cataract
- hereditary disorder
- multiple types cataract 21
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
role in cell
- activation
- apoptosis
- activation in
- expression in
- proliferation
- growth
- quantity
- production in
- migration
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- vesicles
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Maf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- megakaryocyte differentiation
- inner ear development
- regulation of chondrocyte differentiation
- positive regulation of gene expression
- transcription from RNA polymerase II promoter
- lens fiber cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity