NEWGENE_1311658 Gene Summary [Rat]
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_1311658 |
| Official Name | programmed cell death 1 [Source:RGD Symbol;Acc:9464499] |
| Ensembl ID | ENSRNOG00000049797 |
| Bio databases IDs | |
| Aliases | programmed cell death 1 |
| Synonyms | AIMTBS, B7H1, CD279, hPD-1, hPD-l, hSLE1, LOC100911478, Ly101, PD, PD-1, Pd-1 receptor, Pdc1, PhLP, programmed cell death 1, SLEB2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_1311658 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
- immunoreceptor tyrosine switch motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- acute myeloid leukemia
- neoplasia
- epithelial neoplasia
- solid tumor
- breast cancer
- Hodgkin disease
- epithelial cancer
- cancer
- Hodgkin lymphoma
role in cell
- phosphorylation in
- expression in
- apoptosis
- cell death
- growth
- activation in
- activation
- proliferation
- cell viability
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_1311658 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell mediated immune response to tumor cell
- negative regulation of tolerance induction
- apoptotic process
- humoral immune response
- negative regulation of B cell apoptotic process
- adaptive immune response
- positive regulation of T cell apoptotic process
- negative regulation of T cell activation
- negative regulation of immune response
- B cell apoptotic process
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity