Pdcd1 Gene Summary [Mouse]
Predicted to enable signaling receptor activity. Involved in negative regulation of immune response. Acts upstream of or within negative regulation of B cell apoptotic process; negative regulation of tolerance induction; and positive regulation of T cell apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdcd1 |
| Official Name | programmed cell death 1 [Source:MGI Symbol;Acc:MGI:104879] |
| Ensembl ID | ENSMUSG00000026285 |
| Bio databases IDs | |
| Aliases | programmed cell death 1 |
| Synonyms | AIMTBS, B7H1, CD279, hPD-1, hPD-l, hSLE1, LOC100911478, Ly101, PD, PD-1, Pd-1 receptor, Pdc1, PhLP, programmed cell death 1, SLEB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdcd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
- immunoreceptor tyrosine switch motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- acute myeloid leukemia
- neoplasia
- epithelial neoplasia
- solid tumor
- breast cancer
- Hodgkin disease
- epithelial cancer
- cancer
- Hodgkin lymphoma
role in cell
- phosphorylation in
- expression in
- apoptosis
- cell death
- growth
- activation in
- activation
- proliferation
- cell viability
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdcd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell mediated immune response to tumor cell
- negative regulation of tolerance induction
- apoptotic process
- humoral immune response
- negative regulation of B cell apoptotic process
- adaptive immune response
- positive regulation of T cell apoptotic process
- negative regulation of T cell activation
- negative regulation of immune response
- B cell apoptotic process
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity