LOC100909524 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in liver regeneration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in thrombophilia. Orthologous to human SERPINA10 (serpin family A member 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | LOC100909524 |
| Official Name | protein Z-dependent protease inhibitor-like [Source:RGD Symbol;Acc:6503444] |
| Ensembl ID | ENSRNOG00000050761 |
| Bio databases IDs | |
| Aliases | protein Z-dependent protease inhibitor-like |
| Synonyms | CENTERIN, LOC100909524, PZI, Rasp1, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10, serine (or cysteine) peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 10, Serpin10, serpin family A member 10, ZPI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100909524 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Loc100909524 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100909524 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of acrosome reaction
- negative regulation of endopeptidase activity
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- heparin binding