Mia2 Gene Summary [Rat]
Predicted to enable cargo receptor activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; and protein transport. Predicted to act upstream of or within cholesterol homeostasis and triglyceride homeostasis. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Orthologous to several human genes including MIA2 (MIA SH3 domain ER export factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mia2 |
| Official Name | MIA SH3 domain ER export factor 2 [Source:RGD Symbol;Acc:6488546] |
| Ensembl ID | ENSRNOG00000005101 |
| Bio databases IDs | |
| Aliases | MIA SH3 domain ER export factor 2 |
| Synonyms | CTAGE5, D12Bwg0579e, MEA6, MGEA, MGEA6, MIA SH3 domain ER export factor 2, TALI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mia2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Autophagy protein 16 (ATG16)
- cargo receptor activity
- Hyaluronan mediated motility receptor N-terminal
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- enzyme activator activity
- proline rich domain
- transmembrane receptor
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- melanoma
- melanoma cancer
- skin cancer
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- growth
- quantity
- density
- outgrowth
- outgrowth in
- cargo loading in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum exit sites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mia2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- cargo loading into vesicle
- protein secretion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum exit site
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding