SERPINA10 Gene Summary [Human]
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | SERPINA10 |
| Official Name | serpin family A member 10 [Source:HGNC Symbol;Acc:HGNC:15996] |
| Ensembl ID | ENSG00000140093 |
| Bio databases IDs | |
| Aliases | serpin family A member 10, Protein-Z dependent proteinase inhibitor |
| Synonyms | CENTERIN, LOC100909524, PZI, Rasp1, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10, serine (or cysteine) peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 10, Serpin10, serpin family A member 10, ZPI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINA10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the SERPINA10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINA10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of acrosome reaction
- negative regulation of endopeptidase activity
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- heparin binding