AABR07070310.1 Gene Summary [Rat]
Predicted to enable hydrolase activity. Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within elastic fiber assembly. Located in collagen-containing extracellular matrix and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | AABR07070310.1 |
| Official Name | thrombospondin type 1 domain containing 4 [Source:NCBI gene;Acc:315728] |
| Ensembl ID | ENSRNOG00000051221 |
| Bio databases IDs | |
| Aliases | thrombospondin type 1 domain containing 4 |
| Synonyms | AABR07070307.1, AAT12, ADAMTSL-6, AI585901, B230114P05Rik, FLJ13710, FVSY9334, PRO34005, RGD1566296, thrombospondin type 1 domain containing 4, thrombospondin, type I, domain containing 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07070310.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- ADAM-TS Spacer 1
- ADAMTS cysteine-rich domain
- PLAC (protease and lacunin) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- open-angle glaucoma
- Alzheimer disease
- breast carcinoma
- IgA nephropathy
- chronic obstructive pulmonary disease
- familial thoracic aortic aneurysms and dissections
- periodontitis
- idiopathic scoliosis
- cervical cancer
regulates
- MMP9
- SMAD2/3
role in cell
- formation
- assembly
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microfibrils
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07070310.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elastic fiber assembly
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- microfibril
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent
- hydrolase activity