Thsd4 Gene Summary [Mouse]
Predicted to enable hydrolase activity. Acts upstream of or within elastic fiber assembly. Located in microfibril. Is expressed in several structures, including alimentary system; cardiovascular system; connective tissue; forebrain; and metatarsal bone. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human THSD4 (thrombospondin type 1 domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thsd4 |
| Official Name | thrombospondin, type I, domain containing 4 [Source:MGI Symbol;Acc:MGI:2672033] |
| Ensembl ID | ENSMUSG00000032289 |
| Bio databases IDs | |
| Aliases | thrombospondin, type I, domain containing 4 |
| Synonyms | AABR07070307.1, AAT12, ADAMTSL-6, AI585901, B230114P05Rik, FLJ13710, FVSY9334, PRO34005, RGD1566296, thrombospondin type 1 domain containing 4, thrombospondin, type I, domain containing 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thsd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- ADAM-TS Spacer 1
- ADAMTS cysteine-rich domain
- PLAC (protease and lacunin) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- open-angle glaucoma
- Alzheimer disease
- breast carcinoma
- IgA nephropathy
- chronic obstructive pulmonary disease
- familial thoracic aortic aneurysms and dissections
- periodontitis
- idiopathic scoliosis
- cervical cancer
regulates
- MMP9
- SMAD2/3
role in cell
- formation
- assembly
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microfibrils
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thsd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elastic fiber assembly
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- microfibril
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent
- hydrolase activity