Hoxd11 Gene Summary [Rat]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Hoxd11 |
| Official Name | homeobox D11 [Source:RGD Symbol;Acc:7730597] |
| Ensembl ID | ENSRNOG00000051472 |
| Bio databases IDs | |
| Aliases | homeobox D11 |
| Synonyms | E230017H14RIK, Homeobox d11, HOX4, Hox-4.6, HOX4F, Hox-5.4, Hox-5.5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Protein of unknown function (DUF3528)
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- glioblastoma
- glioblastoma cancer
- Cornelia de Lange syndrome
- Wilms tumor
- Wilms tumorigenesis
- endometrioma
- hypoplasia
- osteosarcomagenesis
- soft tissue sarcoma cancer
role in cell
- expression in
- differentiation
- morphology
- development
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- branching involved in ureteric bud morphogenesis
- anatomical structure development
- dorsal/ventral pattern formation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity