Grin1 Gene Summary [Rat]
Enables several functions, including amyloid-beta binding activity; carboxylic acid binding activity; and monoatomic ion channel activity. Involved in several processes, including cellular response to glycine; modulation of chemical synaptic transmission; and positive regulation of dendritic spine maintenance. Located in several cellular components, including dendrite; postsynaptic membrane; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant intellectual developmental disorder 8; cerebral infarction; and developmental and epileptic encephalopathy 101. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grin1 |
| Official Name | glutamate ionotropic receptor NMDA type subunit 1 [Source:RGD Symbol;Acc:2736] |
| Ensembl ID | ENSRNOG00000011726 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor NMDA type subunit 1 |
| Synonyms | DEE101, GluN1, GluRdelta1, GluRzeta1, glutamate ionotropic receptor NMDA type subunit 1, glutamate receptor, ionotropic, NMDA1 (zeta 1), glutamate receptor, ionotropic, NMDA1 (ζ 1), hNR1, M100174, MRD8, NDHMSD, NDHMSR, NMDA1, Nmda nr1, Nmdar, NMDAR1, NMDA Receptor, NMD-R1, NMDZ1, NR1, Rgsc174 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutamate binding
- Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
- ion channel
- N-methyl-D-aspartate selective glutamate receptor
- cytoplasmic domain
- glycine binding
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- tail domain
- phosphatase binding
- extracellular domain
- Receptor family ligand binding region
- calmodulin binding
- calcium channel
- channel/pore class transporter
- calmodulin binding domain
- Ligated ion channel L-glutamate- and glycine-binding site
- amiloride-sensitive sodium channel
- ionotropic glutamate receptor
- enzyme binding
- calcium ion binding
- extracellular ligand-gated ion channel
- protein binding
- receptor binding
- beta-amyloid binding
- ionotropic glutamate receptor binding
- binding protein
- neurotransmitter receptor
- transmembrane domain
- ligand-gated ion channel
- cytosolic tail domain
- voltage-gated ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Grin1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atelectasis
- postoperative pain
- pain
- multiple sclerosis
- lung adenocarcinoma formation
- schizophrenia
- agitation
- autosomal dominant mental retardation type 8
- cyanosis
- autism
role in cell
- expression in
- phosphorylation in
- quantity
- cell death
- morphology
- homeostasis
- long term synaptic depression
- synaptic transmission
- survival
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- membrane fraction
- synaptosomal membrane fractions
- synaptic spine
- synaptic vesicle membrane
- glutaminergic synapse
- cytoplasmic vesicle membrane
- intracellular compartment
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- somatodendritic region
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- basolateral membrane
- dendritic spines
- synaptic vesicles
- neurites
- nerve ending
- synaptosomes
- synapse
- membrane rafts
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- axospinous synapses
- excitatory synapses
- dendritic shafts
- dendritic branches
- coarse fibers
- vesicle fraction
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- calcium ion homeostasis
- synaptic transmission
- visual learning
- brain development
- positive regulation of transcription from RNA polymerase II promoter
- protein heterotetramerization
- response to ethanol
- regulation of membrane potential
- cation transport
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- positive regulation of excitatory postsynaptic membrane potential
- positive regulation of synaptic transmission, glutamatergic
- positive regulation of calcium ion transport into cytosol
- calcium-mediated signaling
- ionotropic glutamate receptor signaling pathway
- propylene metabolic process
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic vesicle
- excitatory synapse
- synaptic membrane
- synapse
- neuron projection
- plasma membrane
- cell surface
- endoplasmic reticulum membrane
- dendrite
- synaptic cleft
- terminal button
- cytoplasm
- postsynaptic membrane
- dendritic spine
- N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- ligand-gated ion channel activity
- calcium channel activity
- calcium ion binding
- signaling receptor activity
- glutamate-gated calcium ion channel activity
- glycine binding
- glutamate binding
- beta-amyloid binding
- N-methyl-D-aspartate selective glutamate receptor activity