Opn1mw Gene Summary [Rat]
Predicted to enable G protein-coupled photoreceptor activity and identical protein binding activity. Predicted to be involved in several processes, including cellular response to light stimulus; phototransduction; and positive regulation of cytokinesis. Located in photoreceptor outer segment. Human ortholog(s) of this gene implicated in blue cone monochromacy; red color blindness; and red-green color blindness. Orthologous to several human genes including OPN1LW (opsin 1, long wave sensitive) and OPN1MW (opsin 1, medium wave sensitive). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opn1mw |
| Official Name | opsin 1, medium wave sensitive [Source:RGD Symbol;Acc:620978] |
| Ensembl ID | ENSRNOG00000051529 |
| Bio databases IDs | |
| Aliases | opsin 1, medium wave sensitive |
| Synonyms | CBBM, CBD, COD5, GCP, GOP, GREEN CONE OPSIN, ML Opsin, M-opsin, Opn1lw, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), opsin 1, medium wave sensitive, Rcp, Rsvp |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Opn1mw often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- photoreceptor activity
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Opn1mw gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- deuteranomaly
- deutan colorblindness
- X-linked cone dystrophy type 5
- Huntington disease
- blue-cone monochromacy
- achromatopsia
role in cell
- expression in
- cell viability
- cytokinesis in
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- growth cone
- photoreceptor outer segments
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Opn1mw gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to light stimulus
- G-protein coupled receptor signaling pathway
- detection of visible light
- visual perception
- phototransduction
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- photoreceptor activity
- G-protein coupled photoreceptor activity