Hbegf Gene Summary [Rat]
Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of glycoprotein biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space and plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hbegf |
| Official Name | heparin-binding EGF-like growth factor [Source:RGD Symbol;Acc:2526] |
| Ensembl ID | ENSRNOG00000018646 |
| Bio databases IDs | |
| Aliases | heparin-binding EGF-like growth factor |
| Synonyms | DIPHTHERIA TOXIN receptor, DTR, DT Receptor, DTS, DTSF, GFHB, HEGFL, Heparin-binding EGF-like growth factor, Heparin-binding egf-like precursor, HEPARIN-binding EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hbegf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- membrane-association domain
- epidermal growth factor receptor binding
- ectodomain
- heparin binding domain
- protein binding
- EGF-like domain
- growth factor
- transmembrane receptor protein tyrosine kinase activator
- cytoplasmic domain
- transmembrane domain
- receptor agonist activity
- cytosolic tail domain
- membrane-proximal domain
- heparin binding
Pathways
Biological processes and signaling networks where the Hbegf gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- glioma formation
- migraines
- gout
- organismal death
- atrial fibrillation
- crescentic glomerulonephritis
- late-onset preeclampsia
- glioma
role in cell
- expression in
- number
- phosphorylation in
- aggregation
- quantity
- formation
- apoptosis
- cell viability
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- raft fractions
- soluble fraction
- insoluble fractions
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- cell-cell contacts
- apical cell surfaces
- basolateral cell surfaces
- basolateral membrane
- membrane rafts
- brush border
- axons
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hbegf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERBB2-ERBB4 signaling pathway
- positive regulation of wound healing
- signal transduction
- ERBB2-EGFR signaling pathway
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- regulation of heart contraction
- cell chemotaxis
- positive regulation of smooth muscle cell proliferation
- muscle organ development
- positive regulation of cell growth
- positive regulation of keratinocyte migration
- wound healing, spreading of epidermal cells
- positive regulation of protein kinase B signaling cascade
- negative regulation of elastin biosynthetic process
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- clathrin-coated endocytic vesicle membrane
- extracellular region
- endocytic vesicle membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- epidermal growth factor receptor binding
- transmembrane receptor protein tyrosine kinase activator activity
- receptor agonist activity
- heparin binding