OPN1MW Gene Summary [Human]

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]

Details

Type
Protein Coding
Official Symbol
OPN1MW
Official Name
opsin 1, medium wave sensitive [Source:HGNC Symbol;Acc:HGNC:4206]
Ensembl ID
ENSG00000268221
Bio databases IDs NCBI: 2652 Ensembl: ENSG00000268221
Aliases opsin 1, medium wave sensitive, cone dystrophy 5 (X-linked)
Synonyms CBBM, CBD, COD5, GCP, GOP, GREEN CONE OPSIN, ML Opsin, M-opsin, Opn1lw, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), opsin 1, medium wave sensitive, Rcp, Rsvp
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OPN1MW often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • 7 transmembrane receptor (rhodopsin family)
  • protein binding
  • photoreceptor activity
  • identical protein binding
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the OPN1MW gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • deuteranomaly
  • deutan colorblindness
  • X-linked cone dystrophy type 5
  • Huntington disease
  • blue-cone monochromacy
  • achromatopsia
regulated by
regulates
role in cell
  • expression in
  • cell viability
  • cytokinesis in
  • density

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • growth cone
  • photoreceptor outer segments
  • cone outer segments

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human OPN1MW gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cellular response to light stimulus
  • G-protein coupled receptor signaling pathway
  • detection of visible light
  • visual perception
  • phototransduction
  • positive regulation of cytokinesis

Cellular Component

Where in the cell the gene product is active
  • plasma membrane
  • photoreceptor outer segment

Molecular Function

What the gene product does at the molecular level
  • identical protein binding
  • photoreceptor activity
  • G-protein coupled photoreceptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.