Pygo1 Gene Summary [Rat]
Enables methylated histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including hematopoietic progenitor cell differentiation; protein localization to nucleus; and spermatid development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | Pygo1 |
| Official Name | pygopus family PHD finger 1 [Source:RGD Symbol;Acc:1594620] |
| Ensembl ID | ENSRNOG00000051813 |
| Bio databases IDs | |
| Aliases | pygopus family PHD finger 1 |
| Synonyms | 2600014C22Rik, LOC100506346, LOC283658, LOC678949, pygopus 1, pygopus family PHD finger 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pygo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding activity, bridging
- PHD finger superfamily
- protein binding
Pathways
Biological processes and signaling networks where the Pygo1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- exencephaly
- cleft lip
- aphakia
regulates
- HAMP
- RNA polymerase II
- luciferase reporter gene
- synthetic promoter
- Xist
- DNA promoter
- DNA endogenous promoter
role in cell
- expression in
- differentiation
- development
- inactivation
- inactivation in
- differentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pygo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- kidney development
- spermatid nucleus differentiation
- canonical Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- protein localization to nucleus
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- methylated histone residue binding