Orc6 Gene Summary [Rat]
Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Orc6 |
| Official Name | origin recognition complex, subunit 6 [Source:RGD Symbol;Acc:1311437] |
| Ensembl ID | ENSRNOG00000024043 |
| Bio databases IDs | |
| Aliases | origin recognition complex, subunit 6 |
| Synonyms | 6720420I10Rik, ORC6L, origin recognition complex subunit 6, origin recognition complex, subunit 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Orc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Middle domain of the origin recognition complex subunit 6
- protein binding
Pathways
Biological processes and signaling networks where the Orc6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- Meier-Gorlin syndrome type 3
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- osteosarcoma
- osteosarcomagenesis
- colorectal cancer
regulates
role in cell
- formation
- morphology
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin fraction
- fibrillar center
- cell periphery
- midbody
- Flemming body
- cytosol
- chromosome
- nucleoplasm
- cleavage furrow
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Orc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
Cellular Component
Where in the cell the gene product is active
- origin recognition complex
- nucleus
- membrane
- cytosol
- nuclear origin of replication recognition complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding