Nav3 Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of interleukin-2 production; and regulation of microtubule polymerization or depolymerization. Predicted to be located in microtubule end and nuclear envelope. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nav3 |
| Official Name | neuron navigator 3 [Source:RGD Symbol;Acc:1306259] |
| Ensembl ID | ENSRNOG00000052157 |
| Bio databases IDs | |
| Aliases | neuron navigator 3 |
| Synonyms | 4732483H20RIK, 9630020C08, 9630020C08Rik, KIAA0938, mKIAA0938, Neuron Navigator 3, POMFIL1, Pomfil1p, RGD1306259, scl00260315.1 244, STEERIN3, unc53H3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nav3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- calponin homology (CH) domain superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- umbilical hernia
- major depression
- breast adenocarcinoma
- osteonecrosis
- colorectal cancer
- systemic mastocytosis
- suicide attempt
- mood disorder
- ophthalmic disorder
regulates
role in cell
- migration
- depolymerization
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nav3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-2 production
- nervous system development
- negative regulation of microtubule depolymerization
- neurogenesis
- positive regulation of microtubule polymerization
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nuclear outer membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule binding