Cstb Gene Summary [Rat]
Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in amyloid fibril formation and negative regulation of peptidase activity. Predicted to act upstream of or within adult locomotory behavior. Predicted to be located in cytoplasm; extracellular space; and nucleolus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome and progressive myoclonus epilepsy 1A. Orthologous to human CSTB (cystatin B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cstb |
| Official Name | cystatin B [Source:RGD Symbol;Acc:2435] |
| Ensembl ID | ENSRNOG00000001201 |
| Bio databases IDs | |
| Aliases | cystatin B |
| Synonyms | Cathepsin B, CPI-B, CST6, Cyb, CYSTATIN B, Cystatin-beta, Cystatin-β, EPM1, EPM1A, PME, stefin B, STFB, ULD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cstb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- endopeptidase inhibitor
- cysteine protease inhibitor activity
- protease binding
- peptidase
- protein binding
Pathways
Biological processes and signaling networks where the Cstb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- metastasis
- Unverricht-Lundborg syndrome
- progressive myoclonic epilepsy
- benign rolandic epilepsy
- seizures
- diabetic nephropathy
- organismal death
- hereditary disorder
role in cell
- apoptosis
- phosphorylation in
- expression in
- proliferation
- accumulation in
- processing in
- formation in
- formation
- cell death
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- intracellular space
- organelle lumens
- Nucleus
- cytosol
- interchromatin granules
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cstb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of proteolysis
- adult locomotory behavior
- negative regulation of peptidase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
- secretory granule lumen
- nucleolus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- RNA binding
- endopeptidase inhibitor activity
- cysteine-type endopeptidase inhibitor activity
- protease binding