Kcna6 Gene Summary [Rat]
Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna6 |
| Official Name | potassium voltage-gated channel subfamily A member 6 [Source:RGD Symbol;Acc:62083] |
| Ensembl ID | ENSRNOG00000052486 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily A member 6 |
| Synonyms | HBK2, KV1.6, KV1.6 alpha subunit, KV1.6 α subunit, MK1.6, potassium voltage-gated channel, shaker-related, subfamily, member 6, potassium voltage-gated channel subfamily A member 6, PPP1R96 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcna6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- delayed rectifier potassium channel
- voltage-gated potassium channel
- subregion I of the P region
- Ion transport protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- hypophagia
- relapsing-remitting multiple sclerosis
- nonarteritic ischemic optic neuropathy
- primary progressive multiple sclerosis
- secondary progressive multiple sclerosis
- nerve injury
regulated by
- levodopa
- SUB1
- kappaM-conopeptide RIIIJ
- dalfampridine
regulates
- triacylglycerol
- methylamine
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- cytosol
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcna6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- potassium channel complex
- intracellular membrane-bounded organelle
- voltage-gated potassium channel complex
- membrane
- cytosol
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- delayed rectifier potassium channel activity