Kcnab1 Gene Summary [Rat]
Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including myoblast differentiation; negative regulation of delayed rectifier potassium channel activity; and skeletal muscle organ development. Located in dendrite; juxtaparanode region of axon; and perikaryon. Part of voltage-gated potassium channel complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnab1 |
| Official Name | potassium voltage-gated channel subfamily A member regulatory beta subunit 1 [Source:RGD Symbol;Acc:61827] |
| Ensembl ID | ENSRNOG00000056697 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily A member regulatory beta subunit 1 |
| Synonyms | AKR6A3, Akr8a8, hKvb3, hKvBeta3, KCNA1B, Kvb1.3, KV-BETA-1, Kv beta1.1, KvBeta3, KV-β-1, mKv(beta)1, mKv(β)1, Potassium channel beta1 subunit, potassium voltage-gated channel, shaker-related subfamily, beta member 1, potassium voltage-gated channel, shaker-related subfamily, β member 1, potassium voltage-gated channel subfamily A regulatory beta subunit 1, potassium voltage-gated channel subfamily A regulatory β subunit 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADPH binding
- Aldo-keto reductase (AKR) superfamily
- aldo-keto reductase
- Aldo/keto reductase family
- potassium channel regulator
- ion channel binding
- protein domain specific binding
- protein binding
- voltage-dependent potassium channel beta subunit, animal
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- Huntington disease
- acute myeloid leukemia
- age-related nuclear cataract disorder
- COVID-19
- restless legs syndrome
- hypertension
- preterm birth
- multinodular goiter
- glioblastoma
role in cell
- activation in
- expression in
- action potential
- afterhyperpolarization
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- axon component
- Cytoplasm
- cytosol
- cytoplasmic face of plasma membrane
- synaptic membrane
- dendrite initial segments
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- potassium channel complex
- voltage-gated potassium channel complex
- cytosol
- juxtaparanode region of axon
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein domain specific binding
- NADPH binding
- aldo-keto reductase (NADP) activity
- ion channel binding
- potassium channel regulator activity