Ak3 Gene Summary [Rat]
Enables adenylate kinase activity and identical protein binding activity. Involved in several processes, including brain development; liver development; and purine nucleotide metabolic process. Located in mitochondrial matrix. Orthologous to human AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak3 |
| Official Name | adenylate kinase 3 [Source:RGD Symbol;Acc:619885] |
| Ensembl ID | ENSRNOG00000052506 |
| Bio databases IDs | |
| Aliases | adenylate kinase 3 |
| Synonyms | 1700018L02RIK, adenylate kinase 3, AI506714, Ak3l, AK3L1, Ak-4, AK6, AKL3L, AKL3L1, FIX, LOC120100014 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ak3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- adenylate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- nucleoside-triphosphate-adenylate kinase
- identical protein binding
- AAA domain
- Adenylate kinase, active site lid
Pathways
Biological processes and signaling networks where the Ak3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- early onset hypertension
regulates
- TNF
- guanosine triphosphate
- ITP
- AMP
- dATP
- ADP
- UTP
role in cell
- signaling in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ak3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UTP metabolic process
- ITP metabolic process
- AMP metabolic process
- ADP biosynthetic process
- nucleoside triphosphate biosynthetic process
- GTP metabolic process
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- GTP binding
- adenylate kinase activity
- ATP binding
- protein binding
- nucleoside triphosphate adenylate kinase activity