AK3 Gene Summary [Human]
The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | AK3 |
| Official Name | adenylate kinase 3 [Source:HGNC Symbol;Acc:HGNC:17376] |
| Ensembl ID | ENSG00000147853 |
| Bio databases IDs | |
| Aliases | adenylate kinase 3 |
| Synonyms | 1700018L02RIK, adenylate kinase 3, AI506714, Ak3l, AK3L1, Ak-4, AK6, AKL3L, AKL3L1, FIX, LOC120100014 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- adenylate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- nucleoside-triphosphate-adenylate kinase
- identical protein binding
- AAA domain
- Adenylate kinase, active site lid
Pathways
Biological processes and signaling networks where the AK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- early onset hypertension
role in cell
- signaling in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- UTP metabolic process
- ITP metabolic process
- AMP metabolic process
- ADP biosynthetic process
- nucleoside triphosphate biosynthetic process
- GTP metabolic process
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- GTP binding
- adenylate kinase activity
- ATP binding
- protein binding
- nucleoside triphosphate adenylate kinase activity