Vcpip1 Gene Summary [Rat]
Enables cysteine-type deubiquitinase activity. Involved in Golgi reassembly; endoplasmic reticulum membrane fusion; and protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be active in synapse. Orthologous to human VCPIP1 (valosin containing protein interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vcpip1 |
| Official Name | valosin containing protein interacting protein 1 [Source:RGD Symbol;Acc:708520] |
| Ensembl ID | ENSRNOG00000006980 |
| Bio databases IDs | |
| Aliases | valosin containing protein interacting protein 1 |
| Synonyms | 4932442A08, 5730421J18Rik, 5730538E15Rik, DUBA3, mKIAA1850, valosin containing protein interacting protein 1, valosin containing protein (p97)/p47 complex interacting protein 1, VCIP135 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vcpip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubl1_cv_Nsp3_N-like
- peptidase
- ubiquitin-specific protease
- VCIP135 N-terminal
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- ANGPT2
- alpha-tocopherol
- lapatinib/pazopanib
role in cell
- degradation in
- ubiquitination in
- JG-231 sensitivity
- assembly
- organization
- DNA damage response
- fusion
- TAK-901 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- Golgi membrane
- Golgi stacks
- synaptic vesicles
- synapse
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vcpip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein K11-linked deubiquitination
- Golgi reassembly
- proteolysis
- endoplasmic reticulum membrane fusion
- response to DNA damage stimulus
- protein ubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- cytoplasm
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity