Clcn7 Gene Summary [Rat]
Predicted to enable chloride transmembrane transporter activity. Involved in response to pH. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in lysosomal membrane. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clcn7 |
| Official Name | chloride voltage-gated channel 7 [Source:RGD Symbol;Acc:61836] |
| Ensembl ID | ENSRNOG00000016976 |
| Bio databases IDs | |
| Aliases | chloride voltage-gated channel 7 |
| Synonyms | chloride channel, voltage-sensitive 7, chloride voltage-gated channel 7, CLC-7, D17Wsu51e, HOD, OPTA2, OPTB4, PPP1R63 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clcn7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Voltage_gated_ClC
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- CBS domain
- Voltage gated chloride channel
- chloride channel
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant osteopetrosis type 2
- autosomal recessive osteopetrosis type 4
- hereditary disorder
- neuronal ceroid lipofuscinosis
- hypopigmentation, organomegaly, and delayed myelination and development
- osteopetrosis
- autosomal recessive osteopetrosis
- cutaneous melanoma
- cutaneous melanoma cancer
- mechanical hyperalgesia
regulates
- ATP5MC2
- chloride
role in cell
- growth
- cell death
- accumulation in
- number
- cell viability
- response
- accumulation
- abnormal morphology
- activation
- excitability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endosomal fractions
- lysosome fractions
- Cytoplasm
- cellular membrane
- lysosome
- Endoplasmic Reticulum
- trans Golgi network
- lysosome membrane
- neurites
- ruffled borders
- early endosomes
- late endosomes
- endolysosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clcn7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transepithelial chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- intracellular membrane-bounded organelle
- membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- antiporter activity
- chloride channel activity
- chloride transmembrane transporter activity
- voltage-gated chloride channel activity