Slco4a1 Gene Summary [Rat]
Enables thyroid hormone transmembrane transporter activity. Involved in thyroid hormone metabolic process. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO4A1 (solute carrier organic anion transporter family member 4A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco4a1 |
| Official Name | solute carrier organic anion transporter family, member 4a1 [Source:RGD Symbol;Acc:620228] |
| Ensembl ID | ENSRNOG00000053430 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 4a1 |
| Synonyms | OATP1, OATP4A1, OATP-E, OATPRP1, POAT, SLC21A12, solute carrier organic anion transporter family member 4A1, solute carrier organic anion transporter family, member 4a1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slco4a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- protein binding
- thyroid hormone transporter
- KAZAL_FS
- organic anion transporter
- prostaglandin transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- primary pulmonary hypertension
- idiopathic pulmonary fibrosis
- diabetes mellitus
- ophthalmic disorder
- human papilloma virus infection
- oral cancer
regulates
- 3-iodothyronamine
- thyroid hormone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slco4a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- sodium-independent organic anion transport
- thyroid hormone transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- prostaglandin transmembrane transporter activity
- thyroid hormone transmembrane transporter activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity