SLCO4A1 Gene Summary [Human]
Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLCO4A1 |
| Official Name | solute carrier organic anion transporter family member 4A1 [Source:HGNC Symbol;Acc:HGNC:10953] |
| Ensembl ID | ENSG00000101187 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family member 4A1 |
| Synonyms | OATP1, OATP4A1, OATP-E, OATPRP1, POAT, SLC21A12, solute carrier organic anion transporter family member 4A1, solute carrier organic anion transporter family, member 4a1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLCO4A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- protein binding
- thyroid hormone transporter
- KAZAL_FS
- organic anion transporter
- prostaglandin transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- primary pulmonary hypertension
- idiopathic pulmonary fibrosis
- diabetes mellitus
- ophthalmic disorder
- human papilloma virus infection
- oral cancer
regulates
- 3-iodothyronamine
- thyroid hormone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLCO4A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- sodium-independent organic anion transport
- thyroid hormone transport
- prostaglandin transport
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- prostaglandin transmembrane transporter activity
- thyroid hormone transmembrane transporter activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity