Scamp5 Gene Summary [Rat]
Involved in regulation of synaptic vesicle endocytosis. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human SCAMP5 (secretory carrier membrane protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scamp5 |
| Official Name | secretory carrier membrane protein 5 [Source:RGD Symbol;Acc:68356] |
| Ensembl ID | ENSRNOG00000054008 |
| Bio databases IDs | |
| Aliases | secretory carrier membrane protein 5 |
| Synonyms | LOC100360612, Sc5, secretory carrier membrane protein 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scamp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCAMP family
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- hereditary disorder
- streptozotocin induced type1 diabetes
- systemic lupus erythematosus
- Huntington disease
- autosomal recessive mental retardation type 41
- pervasive developmental disorder
- global developmental delay
role in cell
- endocytosis
- trafficking in
- size
- endocytosis in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- cellular membrane
- Plasma Membrane
- Golgi membrane
- trans Golgi network
- endosomal membrane
- synaptic vesicles
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scamp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endocytosis
- protein transport
- positive regulation of cytokine production
- positive regulation of calcium ion-dependent exocytosis
- exocytosis
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- recycling endosome membrane
- synaptic vesicle membrane
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding