Slc9a6 Gene Summary [Rat]
Predicted to enable identical protein binding activity; potassium:proton antiporter activity; and sodium:proton antiporter activity. Involved in glial cell activation and regulation of synaptic vesicle lumen acidification. Is active in presynapse. Human ortholog(s) of this gene implicated in Christianson syndrome. Orthologous to human SLC9A6 (solute carrier family 9 member A6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc9a6 |
| Official Name | solute carrier family 9 member A6 [Source:RGD Symbol;Acc:1563582] |
| Ensembl ID | ENSRNOG00000000879 |
| Bio databases IDs | |
| Aliases | solute carrier family 9 member A6 |
| Synonyms | 3732426M05, 6430520C02Rik, mKIAA0267, MRSA, MRXSCH, NHE-6, RGD1563582, Slc9a6 predicted, solute carrier family 9 member A6, solute carrier family 9 (sodium/hydrogen exchanger), member 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc9a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium/hydrogen exchanger family
- cytoplasmic domain
- Na+/H+ antiporter, bacterial form
- potassium:hydrogen antiporter
- sodium/hydrogen exchanger 3
- protein binding
- cytosolic tail domain
- identical protein binding
- transporter
- sodium:hydrogen antiporter
Pathways
Biological processes and signaling networks where the Slc9a6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X linked mental retardation syndromic christianson type
- Alzheimer disease
- hereditary disorder
- mental retardation
- alkalinization
- productive infection by HIV-1
role in cell
- apoptosis
- production in
- phosphorylation in
- quantity
- acidification
- activation
- morphogenesis
- extension
- arborization
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- presynaptic regions
- cell surface
- endosomes
- Golgi Apparatus
- endoplasmic reticulum membrane
- mitochondrial membrane
- endosomal membrane
- synaptic vesicles
- neurites
- synapse
- recycling endosomes
- early endosomes
- late endosomes
- cytoplasmic vesicles
- microsomal membrane
- axons
- dendrites
- axon terminals
- sorting endosomes
- perinuclear recycling endosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc9a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intracellular pH
- ion transport
- potassium ion transmembrane transport
- axon extension
- neuron projection morphogenesis
- establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- late endosome membrane
- intracellular membrane-bounded organelle
- mitochondrion
- recycling endosome
- recycling endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- potassium:hydrogen antiporter activity
- sodium:hydrogen antiporter activity