Pacsin1 Gene Summary [Rat]
Enables phospholipid binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of dendrite development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in axon terminus; perinuclear region of cytoplasm; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pacsin1 |
| Official Name | protein kinase C and casein kinase substrate in neurons 1 [Source:RGD Symbol;Acc:3247] |
| Ensembl ID | ENSRNOG00000054603 |
| Bio databases IDs | |
| Aliases | protein kinase C and casein kinase substrate in neurons 1 |
| Synonyms | A830061D09Rik, H74, mKIAA1379, protein kinase C and casein kinase substrate in neurons 1, SDPI, syndapin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pacsin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- phospholipid binding
- cytoskeletal protein binding
- variable domain
- NPF motif
- Fes/CIP4, and EFC/F-BAR homology domain
- coiled-coil domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Pacsin1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- tonic-clonic seizure
- insomnia
- metabolic syndrome X
- diabetic nephropathy
- systemic autoimmune syndrome
- androgenic alopecia
- pneumonia
role in cell
- binding in
- accumulation in
- production in
- quantity
- number
- recruitment
- branching
- diameter
- morphogenesis
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- soluble fraction
- glutaminergic synapse
- periactive zone
- perinuclear region
- membrane surface
- Plasma Membrane
- vesicles
- Golgi Apparatus
- membrane ruffles
- synaptic membrane
- growth cone
- neurites
- synaptosomes
- synapse
- filopodia
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
- ribbon synapse
- dendritic shafts
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pacsin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane tubulation
- negative regulation of endocytosis
- cytoskeleton organization
- synaptic vesicle endocytosis
- neuron projection morphogenesis
- protein localization in membrane
- actin filament organization
- regulation of endocytosis
- positive regulation of dendrite development
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- endosome
- cytoplasm
- cytosol
- ruffle membrane
- synapse
- plasma membrane
- axon terminus
- COPI-coated vesicle
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cytoskeletal protein binding
- phospholipid binding