Dnm1 Gene Summary [Rat]
Enables several functions, including D2 dopamine receptor binding activity; SH3 domain binding activity; and enzyme binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Located in Golgi apparatus; cytoplasmic vesicle; and varicosity. Part of protein-containing complex. Is active in presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31A and developmental and epileptic encephalopathy 31B. Orthologous to human DNM1 (dynamin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnm1 |
| Official Name | dynamin 1 [Source:RGD Symbol;Acc:71096] |
| Ensembl ID | ENSRNOG00000033835 |
| Bio databases IDs | |
| Aliases | dynamin 1 |
| Synonyms | DEE31, DEE31A, DEE31B, DNM, DYNAMIN 1, EIEE31, Ftfl, mKIAA4093 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3729)
- G-protein-coupled receptor binding
- enzyme
- identical protein binding
- proline rich domain
- Dynamin family
- nucleotide-binding domain
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- assembly domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- Dynamin GTPase effector domain
- proline glycine arginine motif
- GTP binding domain
- PXXP Class I motif
- protein kinase binding
- enzyme binding
- GTPase activating domain
- GTPase
- central domain
- protein binding
- Pleckstrin homology-like domain
- SH3-domain binding
- arginine proline-rich domain
- binding protein
- GTPase domain
- GDP binding
- Dynamin central region
- protein homodimerization
Pathways
Biological processes and signaling networks where the Dnm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- hyperglycemia
- early infantile epileptic encephalopathy type 31
- developmental and epileptic encephalopathy type 31B
- hereditary disorder
- developmental epileptic encephalopathy
- insomnia
- epileptic encephalopathy
- DNM1-related disorder
- impaired glucose tolerance
regulated by
- PKC
- PPP3R1
- lipopolysaccharide
- phosphatidylserine
- progesterone
- Calcineurin (complex)
- tetradecanoylphorbol acetate
- nicotine
- Yi-Gan San
- voltage-gated calcium channel
role in cell
- expression in
- migration
- cell viability
- apoptosis
- activation in
- formation
- endocytosis
- activity-dependent bulk endocytosis
- vacuolation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- myelin enriched fraction
- detergent-insoluble fractions
- membrane fraction
- rod photoreceptor terminal
- glutaminergic synapse
- axon component
- presynaptic regions
- Golgi region
- outer membranes
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- microtubules
- actin filaments
- actin bundles
- cytosol
- synaptic membrane
- acrosome
- sperm head
- proacrosomic vesicles
- synaptic vesicles
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- endocytotic vesicle
- clathrin-coated pits
- membrane processes
- perikaryon
- dendrites
- presynaptic terminals
- ribbon synapse
- clathrin-coated vesicles
- detergent-soluble fraction
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- endosome organization
- synaptic vesicle budding from presynaptic membrane
- protein homooligomerization
- regulation of synaptic transmission
- endocytosis
- receptor internalization
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- membrane coat
- endocytic vesicle
- extracellular vesicular exosome
- cytoplasm
- coated pit
- chromaffin granule
- synapse
- photoreceptor inner segment
- cell projection
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein kinase binding
- phosphatidylinositol-4,5-bisphosphate binding
- identical protein binding
- protein binding
- protein homodimerization activity
- RNA binding
- GTPase activity
- GDP binding
- microtubule binding