Nedd9 Gene Summary [Rat]
Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of dendritic spine maintenance; positive regulation of immunological synapse formation; and regulation of cell migration. Predicted to act upstream of or within activation of GTPase activity. Predicted to be located in several cellular components, including basolateral plasma membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nedd9 |
| Official Name | neural precursor cell expressed, developmentally down-regulated 9 [Source:RGD Symbol;Acc:1306276] |
| Ensembl ID | ENSRNOG00000014548 |
| Bio databases IDs | |
| Aliases | neural precursor cell expressed, developmentally down-regulated 9 |
| Synonyms | CAS2, CAS-L, CASS2, enhancer of filamentation 1, HEF1, MEF1, neural precursor cell expressed, developmentally down-regulated 9, neural precursor cell expressed, developmentally down-regulated gene 9, p105, P105hef1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nedd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- substrate domain
- FAT-like_CAS_C
- serine-rich region
- protein kinase binding
- protein binding
- helix-loop-helix domain
- Src-homology 2 binding domain
- Serine rich protein interaction domain
- Serine_rich_CAS
- Src Homology 3 domain superfamily
- Crk-Associated Substrate C-terminal domain
Pathways
Biological processes and signaling networks where the Nedd9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- prostate cancer
- coronary artery disease
- hypoplasia
- prostatic carcinoma
- epithelial cancer
- epithelial uterine cancer
- tumorigenesis
- small cell lung carcinoma
role in cell
- expression in
- quantity
- proliferation
- migration
- apoptosis
- invasion by
- production in
- adhesion
- phosphorylation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- cell periphery
- perinuclear region
- focal adhesions
- Plasma Membrane
- basal bodies
- centrosome
- immunological synapses
- asters
- cytosol
- basolateral membrane
- nucleoplasm
- spindle pole
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nedd9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- signal transduction
- positive regulation of protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell adhesion
- positive regulation of substrate adhesion-dependent cell spreading
- lymphocyte migration into lymphoid organs
- learning or memory
- cell division
- integrin-mediated signaling pathway
- regulation of actin cytoskeleton organization
- positive regulation of osteoclast differentiation
- positive regulation of immunological synapse formation
- cell migration
- actin filament bundle assembly
- negative regulation of cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- spindle pole
- Golgi apparatus
- plasma membrane
- immunological synapse
- nucleoplasm
- nucleus
- focal adhesion
- mitotic spindle
- cytoplasm
- cell cortex
- spindle
- cytosol
- basolateral plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding